Grapefruit and High Blood Pressure Medications

Consuming grapefruit juice or grapefruit while taking high blood pressure medications can be very dangerous. Grapefruit juice blocks enzymes in the small intestine, breaking down medications and preventing their absorption into the body. Grapefruit and grapefruit juice can reduce the absorption of certain high blood pressure medications, including tenormin (Atenolol) and talinolol (Cordanum). One glass of grapefruit juice can elicit a drug-blocking effect that may persist for longer than 24 hours.

Fast Facts:

  • The substance that produces this interaction is found in both fresh grapefruit and grapefruit juice.
  • Grapefruit and grapefruit juice can also increase the absorption of some medications with the potential to turn a normal dose into an overdose.
  • Some prescription medications now have warning labels against consuming grapefruit or grapefruit juice.